Similarly, in lung cancer, the circRNAs, namely, hsa_circ_0051620| SLC1A5 and hsa_circ_0066954| POLQ, are upregulated and are shown to interact with and regulate driver genes, namely, ADAM17, CDH2, RUNX2, and ZBTB18, through miR-338-3p. This evidence concerns the gene RUNX2 and lung carcinoma.