In the lung cancer, the driver triad hsa_circ_0051620| SLC1A5–hsa-miR-338-3p—CDH2 and hsa_circ_0066954| POLQ–hsa-miR-338-3p—CDH2 shows the downregulation of the driver gene CDH2, which increases the survival of the patients. The gene discussed is CDH2; the disease is lung carcinoma.