Specifically, the single nucleotide polymorphism E487K Farrés et al. (1994), Larson et al. (2007) residing in the oligmerization domain, resulting in the ALDH2*2 variant, is related to complications in cardiovascular disease Chen et al. (2019), cancer Seitz and Stickel (2010), alcohol intolerance Chang et al. (2017) and late onset Alzheimer’s disease (Kamino et al., 2000). The gene discussed is ALDH2; the disease is Alzheimer disease.