ALDH2 and early-onset autosomal dominant Alzheimer disease: Specifically, the single nucleotide polymorphism E487K Farrés et al. (1994), Larson et al. (2007) residing in the oligmerization domain, resulting in the ALDH2*2 variant, is related to complications in cardiovascular disease Chen et al. (2019), cancer Seitz and Stickel (2010), alcohol intolerance Chang et al. (2017) and late onset Alzheimer’s disease (Kamino et al., 2000).