A study on the mechanism of miRNA in pulmonary sarcoidosis proved that miR-34a along with miR-155 enhance the secretion of interferon-gamma and negatively modulate SIRT-1, therefore inhibiting NF-κB transcription, as well as deacetylate the p53 protein, ultimately inactivating p53-regulated transcription and apoptosis (Kachamakova-Trojanowska et al., 2018). This evidence concerns the gene TP53 and pulmonary sarcoidosis.