To identify potential biomarkers for evaluating disease severity in patients with ILD-pSS, the clinical implications of the top 20 DEGs (Figure 2) were evaluated, with clinical parameters including ESSDAI score, ESR, C-reactive protein, forced vital capacity, forced expiratory volume in 1 s, and carbon monoxide diffusing capacity of the lung (DLCO). This evidence concerns the gene CRP and peeling skin syndrome.