There was a significant difference in HbA1c level, but not FPG level, among the albumin intervals, and the mean HbA1c levels significantly decreased from 5.86 to 5.67% (P < 0.001 for the trend; Supplementary Figure 2), which ranged across the threshold of HbA1c-defined pre-diabetes (5.7%). The gene discussed is ALB; the disease is diabetes mellitus.