However, with the change of albumin levels from the first to fifth albumin quintile, mean HbA1c value ranged across the threshold of HbA1c-defined pre-diabetes and the difference in proportion of HbA1c-defined pre-diabetic people was up to 12%, which demonstrated that albumin levels interfere with HbA1c-defined discrimination between pre-diabetes and normoglycemia in all participants. The gene discussed is ALB; the disease is diabetes mellitus.