Remarkably, ER-localization of GALNTs in the GALA pathway induces O-Glycosylation of the matrix metalloprotease MMP14 and ER-resident Calnexin, thus drives MMP14 activation and Calnexin/ERp57 cell surface distribution, respectively, both of which promote ECM degradation and tumor development (Nguyen et al., 2017; Ros et al., 2020). The gene discussed is MMP14; the disease is neoplasm.