For example, in both human and murine with allergic asthma, the axis ACh/M1-M3 receptor is involved in the increasing of ASM mass (Kistemaker et al., 2014), enhances IL-8 synthesis (Oenema et al., 2010), mucin expression (Kistemaker and Gosens, 2015), and collagen synthesis by fibroblasts (Matthiesen et al., 2006). This evidence concerns the gene CXCL8 and allergic asthma.