TP53 and neoplasm: Patients in pattern A had higher DNA repair, p53, hypoxia, and EMT signaling pathway enrichment scores (Figures 2B,C), and activation of HIF-1 and Notch signaling were observed in GSEA analysis (Supplementary Figure 2A and Supplementary Table 6), suggesting greater tumor proliferation activity in pattern A, which explained the reason of shorter median DFS in pattern A (Figure 1F).