TP53 and renal cell adenocarcinoma: In addition, ubiquitin factors involved in key signaling of renal cell cancer, such as p53, PI3K/Akt, and Angiogenesis, are being increasingly identified (Ma et al., 2015; Guo et al., 2019; Hao et al., 2019; Yu et al., 2019; Zhang E. et al., 2020).