Notably, TGFβ signaling was negatively correlated to ubiquitination signaling (Figure 5A), and Fukasawa et al. (2010) showed that the ubiquitination degradation process of TGFβ-RII mediated by Smurf2 was significantly enhanced in renal cell cancer, which might be the reason for the TGFβ signaling attenuation in ccRCC. The gene discussed is TGFB1; the disease is nonpapillary renal cell carcinoma.