For a further evaluation of TRIM71 as a candidate gene associated with human male infertility, we screened 908 infertile patients - including those with SCO from MERGE - for variants in TRIM71. We identified 11 different rare (MAF ≤ 0.001) heterozygous TRIM71 variants, including the aforementioned LoF variant and 10 missense variants, present in a total of 14 infertile individuals with severely impaired spermatogenesis and varying histological phenotypes (Figures 6D–F and Table 1). Here, TRIM71 is linked to Infertility.