Indeed, TRIM71 is known to promote self-renewal of neural progenitor cells (Chen et al., 2012), and TRIM71 variants affecting its NHL domain have been associated with human congenital hydrocephalus, a brain developmental disease characterized by enlarged brain ventricles due to an abnormal accumulation of cerebrospinal fluid (Furey et al., 2018). Here, TRIM71 is linked to congenital hydrocephalus.