PIK3CA and neuroblastoma: In the anaplastic lymphoma kinase (ALK)/MYCN-driven NB, activation through the downstream signaling pathways of ALK (PI3K/AKT/MAPK, RAS/RAF/MEK, and JAK/STAT3) may enhance the propagation and maintenance of the stem cell-like sub-population in NB (Du et al., 2014).