In support of this, various studies have implicated the involvement of HGF/c-Met in many human malignancies including high-grade brain tumors (Abounader and Laterra, 2005) such as glioblastomas (GBM; Koochekpour et al., 1997), DIPGs (Paugh et al., 2011; Puget et al., 2012), high-risk NBs (Hecht et al., 2004), and MBs (Binning et al., 2008). This evidence concerns the gene HGF and Nijmegen breakage syndrome.