c-Met is a direct transcriptional target of WNT/β-catenin.MET is co-expressed with CD133 and/or CD15.MET-overexpression correlates with higher clonogenic survival.c-Met expressing cells were preferentially localized in perivascular regions GSCs.Stimulation of c-Met signaling pathway increased expression of Oct4, Nanog, and Klf4.HGF induced c-Met activation was most pronounced in the SHH subgroup of medulloblastoma. This evidence concerns the gene KLF4 and medulloblastoma.