HGF and cancer: Interestingly, sole inhibition of CDK4/6 stimulated an NF-κB-induced upregulation of HGF, brain-derived neurotrophic factor, and nerve growth factor, which led to c-Met and TrkA-B pathway activation (Olmez et al., 2018), implicating the biochemical mechanisms by which these aggressive cancers attempt to evade therapeutic interventions.