High-risk NB was also reported to harbor epigenetic dysregulation including elevation of enhancer of zeste homolog 2 (EZH2), which is associated with enrichment of H3K27me3 at the promoters of tumor suppressor genes such as CASZ1, RUNX3, NGFR (p75), and NTRK1 (TrkA; Wang et al., 2012). The gene discussed is EZH2; the disease is neuroblastoma.