Signaling through the HGF/c-Met pathway was reported to trigger the upregulation and secretion of the pro-angiogenic VEGF in malignant glioma cells thereby inducing the proliferation of neuromicrovascular endothelial cells within the brain cancers via a paracrine and autocrine loop signaling (Moriyama et al., 1998). The gene discussed is HGF; the disease is brain cancer.