A class of bioactive lipid metabolites called cyclooxygenase (COX) oxylipins (e.g., prostaglandins, leukotrienes) has been shown to be elevated in diseased kidneys of rodent models of NPH (pcy/Nphp3 and jck/Nek8/Nphp9 mice and Han:SPRD-Cy/Anks6/Nphp16 rats) and other cystic kidney diseases (Ibrahim et al., 2014; Yamaguchi et al., 2014; Monirujjaman et al., 2017). This evidence concerns the gene NEK8 and normal pressure hydrocephalus.