For example, rodent models of infantile NPH (Han:SPRD-Cy/Anks6/Nphp16 rats and pcy/nphp3 mice) treated with the anti-inflammatory drug methylprednisolone showed reduced fibrosis and preserved kidney function compared to untreated animals (Gattone et al., 1995). This evidence concerns the gene NPHP3 and normal pressure hydrocephalus.