CEP290 and normal pressure hydrocephalus: In the context of NPH, octreotide was shown to significantly decrease cAMP levels and to rescue cilia defects and abnormal 3D spheroid phenotypes in Nphp3, Cep290/Nphp6 and Rpgrip1l/Nphp8 knockdown IMCD3 cells (Ghosh et al., 2012).