Kidney-specific knockout of Aatf (DNA damage response target Apoptosis Antagonizing Transcription Factor), encoding a regulator of p53 during DDR, also leads to phenotypes similar to juvenile NPH including tubular atrophy, interstitial fibrosis and cysts at the corticomedullary junction (Jain et al., 2019). This evidence concerns the gene TP53 and Atrophy.