Statins were shown to improve CKD in various animal models (Ecder, 2016) and were also shown to improve renal function in the Cy/Anks6/Nphp16 rat model, likely through an effect on the renin-angiotensin system (Gile et al., 1995; Zafar et al., 2007). This evidence concerns the gene ANKS6 and chronic kidney disease.