AVPR2 and normal pressure hydrocephalus: Pharmacological interventions aimed at restoring aberrant signal transduction (for example V2R antagonists) or dysregulated cell cycle (for example CDK inhibitors) as well as the use of immunomodulatory drugs (for example senolytic drugs) have improved cystic phenotypes in zebrafish and rodent models of NPH (Gattone et al., 2003; Bukanov et al., 2006; Jin et al., 2020).