Of note, part of the effects of roscovitine, and also of its derivative CR8, could however be linked to its potent inhibition of Casein Kinase 1 family members which expression pattern is perturbed in cystic mouse model including infantile NPH models (pcy/Nphp3, Jck/Nek8/Nphp9) (Billot et al., 2018). Here, NPHP3 is linked to normal pressure hydrocephalus.