ATM and lung cancer: After autophagy is initiated, a series of phagy activities can be carried out through lysosomes to remove radiation-induced injury In lung cancer H1299 cells, radiotherapy-induced DNA damage regulates cellular autophagy through the ATM–MAPK14 pathway, thereby regulating the radiosensitivity of H1299 cells (Gewirtz, 2014; Liang et al., 2015).