NPPB and heart disorder: Besides the commonly downregulated genes like Spp1 or the transcription factors Tcf7l2 and Cebpd, other differentially expressed genes (Pdk4 and S100a6 in coronary disease and Nppa, Nppb, and Dkk3 in dilated cardiomyopathy) may help to identify specific mechanisms associated with these two cardiac diseases (Wang et al., 2020; Figure 1).