More interestingly, YAP regulates the activity of key enzymes involved in the serine pathway in breast cancer (Wu et al., 2017), and YAP-induced serine/glycine metabolism was reported to be regulated by phospholipase C epsilon (PLCε) in prostate cancer (PCa) (Duan et al., 2020). This evidence concerns the gene PLCL1 and Familial prostate cancer.