Notably, CDX2, one of the YAP target genes that is an intestinal-specific transcription factor that regulates the regeneration and differentiation of intestinal epithelial cells, as well as SATB2, a highly sensitive and specific marker for highly differentiated neuroendocrine tumors at the rectal/straight B junction, were expressed in tumor organoids as revealed by the immunohistochemistry analysis (Figure 5D). Here, CDX2 is linked to neuroendocrine neoplasm.