ALS was first associated with exosome trafficking in 2007 when a study showed the transport of both WT and mutant Cu/Zn superoxide dismutase (SOD1) by exosomes in a cell model for ALS (mouse neuron-like NSC-34 overexpressing human mutant SOD1) (Gomes et al., 2007). Here, SOD1 is linked to amyotrophic lateral sclerosis.