TARDBP and Alzheimer disease: Some reports have shown the presence of higher levels of Aβ1–42 and TAR DNA-binding protein 43 (TDP43) and decreased levels of synaptic proteins, as synaptophysin, synaptotagmin, and 25-kDa synaptosomal-associated protein (SNAP-25), in NDEs from AD patients (Fiandaca et al., 2015; Goetzl et al., 2016, 2018).