Indeed, it was observed that APP goes through cleavage inside exosomes, with existing evidence that products resulting from APP processing are present in exosomes from AD human and mouse AD model brains, evidencing the exosome intervention in the pathological process (Vingtdeux et al., 2007; Sharples et al., 2008; Perez-Gonzalez et al., 2012; Guix et al., 2017; Laulagnier et al., 2018). Here, APP is linked to Alzheimer disease.