MMP2 and melanoma: Previous studies have shown that the expression of MMPs is linked to structural changes in many different cell types: MMP2 activation impacts actin cytoskeletal organization in HTM cells resulting in significant morphological changes (Sanka et al., 2007), alterations in cell shape in melanoma cells have been linked to MMP9 suppression (MacDougall and Kerbel, 1995), contractility of cultured cardiomyocytes is associated with MMP2 expression (Bildyug et al., 2015; Bildyug, 2016).