NLRP3 and cryopyrin-associated periodic syndrome: Cryopyrin-associated periodic syndrome (CAPS) is an inherited autoinflammatory disease with hyperactive nod-like receptor protein 3 (NLRP3) (Ohnishi et al., 2012), an inflammasome as one of the best characterized intracellular multi-protein complexes is a critical determinant of a wide range of different autoinflammatory conditions (Swanson et al., 2019).