Elevated IL-6, IL-17A, and CXCL10 (C-X-C motif chemokine ligand 10) and lower IL-17A contributed the to the cytokine storm in MIS-C whereas IL-17A is significantly elevated in KD (17), suggesting a difference in the underlying immunopathology between KD and MIS-C. This evidence concerns the gene IL17A and COVID-19–associated multisystem inflammatory syndrome in children.