CACNA1E and Werner syndrome: In contrast, in 22 infants with WS, 8 cases (7/22, 31.8%) were caused by pathogenic or likely pathogenic variants from a variety of genes, including GABRA1, GABRA2, KCNT1, SCN3A, CACNA1E, PHGDH, and PRRT2 (in del 16p11.2).