Specifically, for each 2-fold increase in the maternal prenatal total IgE, the risk of ADHD increased by 10% (Model 1; RR 1.10, 95% CI 1.05–1.15; p < 0.001); similarly, for each 2-fold increase in the maternal 1-month total IgE, the risk of ADHD increased by 8% (Model 1; RR 1.08, 95% CI 1.04–1.13; p < 0.001). Here, IGHE is linked to attention deficit-hyperactivity disorder.