They found that LMP1 can activate the transcription nuclear factor (NF)-kappa B signaling pathway, and the activated NF-kappa B caused increased expression levels of two downstream target genes, syndecan2 (SDC2) and synaptotagmin-like-4 (SYTL4) directly in NPC cells. The gene discussed is SYTL4; the disease is nasopharyngeal carcinoma.