It can also be concluded that KSHV alters host cells metabolism mainly through the activation of viral oncogenes or the common host metabolic regulators such as HIF-1α and c-Myc, which is similar as that has been demonstrated in the EBV-transformed B-cell lymphomas (Piccaluga et al., 2018). The gene discussed is MYC; the disease is B-cell non-Hodgkin lymphoma.