Increasing evidence shows that KSHV reprograms host cell metabolism mainly through targeting directly regulation of metabolic enzymes at the transcriptional or translational levels, or indirectly activating metabolic regulators that are commonly occurred in cancer cells, such as HIF-1α, c-MYC, AMPK and so on, to alter host metabolic gene expression (Table 1). The gene discussed is MYC; the disease is cancer.