MLX and cancer: Consistence with the discovery that MondoA/Mlx signaling pathway is essential for regulation of glutaminolysis in cancer cells, KSHV also induces expression of the heterodimeric transcription factors c-Myc-Max and their related heterodimer MondoA-Mlx to upregulate glutamine transporter SLC1A5, leading to increased glutamine uptake for glutaminolysis in the KSHV-infected endothelial cells (Sanchez et al., 2015).