During latent infection, it is not only KSHV-encoded LANA protein upregulates the glutaminase and glutamate by activating c-Myc, the latent viral protein Kaposin A also upregulates expression of the metabotropic glutamate receptor 1 (mGluR1 receptor) by binding and sequestering host REST (RE-1 Silencing Transcription Factor) in the cell cytoplasm to relieve the REST-mediated suppression of the mGluR1 gene. Here, GRM1 is linked to disease arising from reactivation of latent virus.