Notably, LPS could react with toll like receptor 4 (TLR4), inducing phagocytic cells to generate a variety of proinflammatory cytokines, such as IL-1β, tumor necrosis factor α (TNF-α), and IL-6, which is suggested to be a key pathway in sepsis pathophysiology (Bosmann and Ward, 2013). Here, TLR4 is linked to Sepsis.