Additionally, lncRNA HOXA-AS2 expression was diminished in patients with sepsis, CLP-induced sepsis mice, and LPS-induced HK-2 cells; in vitro studies found that overexpression lncRNA HOXA-AS2 reduced cell apoptosis and inflammation by targeting miR‐106b‐5p and hindering the Wnt/β‐catenin and NF‐κB pathway (Wu et al., 2020). This evidence concerns the gene NFKB1 and Sepsis.