AKT1 and Sepsis: reported that lncRNA MALAT1, through interaction with EZH2, promoted Akt-1 phosphorylation, decreased BRCA1 expression, and exported BRCA1 from the nucleus, thus promoting skeletal muscle cell apoptosis and inflammatory responses, and ultimately accelerating the progression of sepsis in vivo and in vitro (Yong et al., 2020).