Gain- and loss-of-function experiments in LPS-induced sepsis rats and H9c2 cell line revealed that lncRNA SOX2 could aggravate cardiac function and mitochondrial dysfunction by targeting SOX2 (Chen et al., 2019); therefore lncRNA could influence the of mitochondrial function and thus participate in the process of sepsis-induced heart dysfunction. The gene discussed is SOX2; the disease is Sepsis.