ERBB2 and neoplasm: Furthermore, some oncogenes, such as ErbB2(erb-b2 receptor tyrosine kinase 2), PTEN (phosphatase and tensin homolog), and PI3KCA (phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha) promote tumor progression via the phosphorylation of BCAR1 (27).