AKT1 and neoplasm: Similarly, circAKT3 encodes a 174aa protein (AKT3-174aa); AKT3-174aa (but not circ-AKT3) exerts a tumor-suppressive role by negatively regulating the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway in glioblastoma (GBM) (59).