For example, circPPP1R12A, which is produced by exons 24/25 of PPP1R12A, encodes a 73 amino-acid small peptide (named “PPP1R12A-73aa peptide”); it is circPPP1R12A-73aa rather than circPPP1R12A that has a tumor-suppressor role in colon cancer because it activates the Hippo-YAP signaling pathway (58). This evidence concerns the gene PPP1R12A and colonic neoplasm.