Mechanistically, circZKSCAN1 to suppress cell stemness in HCC by regulating the function of the RBP fragile X mental retardation protein (FMRP) and blocking the binding between FMRP and β-catenin-binding protein-cell cycle and apoptosis regulator 1, thereby subsequently reducing the activity of the Wnt/β-catenin pathway (109). The gene discussed is FMR1; the disease is hepatocellular carcinoma.