Wada Y and colleagues constructed a model based on 8 gene expression (BIRC5, CDC20, CDH2, CENPW, JPH1, MAD2L1, NEIL3, and POC1A), which predicts the recurrence of cholangiocarcinoma with AUC of ROC=0.92 (17). This evidence concerns the gene NEIL3 and cholangiocarcinoma.