In addition, when ANXA5 protein was applied to the murine melanoma xenograft model, tumor size and angiogenesis were remarkably reduced by suppressing VEGF expression (17), which implies that ANXA5 protein might be used as a kind of treatment agent; when ANXA5 was managed to form a complex with TRAIL, it can promote the TRAIL-induced apoptosis and increase cell sensibility to TRAIL (17, 18). This evidence concerns the gene ANXA5 and melanoma.