ANXA5 and cholangiocarcinoma: It was reported that ANXA5 can promote cell proliferation and metastasis, while it can suppress apoptosis in the cell lines of cholangiocarcinoma (9), renal carcinoma (12), and glioblastoma multiforme cells (11) which is contrary to our results, suggesting that ANXA5 may play a different role in different tumor cells, and in gastric cancer, it acted as tumor suppressor gene.