PCAF was reported to function as tumor suppressor in the case of Hepatocellular carcinoma (23, 61), gastric cancer (62), lung adenocarcinoma (63) and colorectal cancer (64) while, in other cancers such as medulloblastoma and glioblastoma it contributes to cytoprotective events that help cancer cells to survive, evade executing cell death programs and invade other tissues (65). The gene discussed is KAT2B; the disease is lung adenocarcinoma.