However, analyzing the previously reported stem surface antigens (Figure 4B), we demonstrated an almost complete restoration of the expression of CD133 in the two melanoma cell lines, CD44 in the colon carcinoma and CD243 in all the three cell lines to control levels, after the reintroduction of the complete uPAR sequence or only its 3’UTR, proving that providing back PLAUR 3’UTR is sufficient to revert the expression of the stem-related markers. This evidence concerns the gene PROM1 and melanoma.