EGFR and cancer: The relationship between EGFR and cell cycle has been primarily elucidated by examining the effects of specific EGFR-targeting agents on cancer cells: attenuation of EGFR growth signaling by various therapeutic agents (i.e. EGFR antisense, monoclonal antibodies against EGFR, or specific tyrosine kinase inhibitors) results in cell cycle arrest in many tumor systems (115, 116).