PLAUR and colon carcinoma: To accomplish such aim, we used previously obtained and selected individual clones (18), after CRISPR-mediated uPAR KO, which were called A375 PL1 from A375p, M6 A5 from A375M6 (melanoma cell lines) and HCT116 A3 from HCT116 (colon carcinoma cell line).