HOTAIR and Familial prostate cancer: In renal cell carcinoma, HOTAIR functions as a ceRNA for miR-217 to facilitate HIF-1α expression and upregulates AXL level promoting renal cell carcinoma proliferation, migration, and EMT process, and inhibiting apoptosis (31). In prostate cancer, lncRNA-ROR significantly increases the levels of miR-145 in CD44+/CD133+ human prostate cancer stem cells.