IRF7 and colorectal carcinoma: The action of the more potent DNMTi 5-aza-2’-deoxycytidine (decitabine) in CRC was partly attributed to the activation of melanoma differentiation-associated protein 5 (MDA5)/MAVS sensing of HERV-derived dsRNA, and subsequent activation of interferon regulatory factor 7 (IRF7) (103).