SMAD4 and neoplasm: To predict the one-year recurrence risk, the Brier scores of the final model (rad-score + ΔCA19-9 ≥80% decrease + tumor differentiation + lymph node metastasis + LVI + SMAD4 expression + adjuvant chemotherapy) in the training and validation cohorts were 0.14 and 0.20, which corresponded to IPA values of 30.6 and 20.6%, respectively.