Collectively these results and ongoing trials provide new insights into the clinical efficacy of ruxolitinib-based combined intervention in CP-CML, and even other refractory Philadelphia chromosome-positive diseases such as BCR-ABL–positive acute lymphoblastic leukemia (ALL) and atypical chronic myeloid leukemia. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.