As a novel diagnostic method for NB, the mRNAs of five neuroblastoma markers (NB5 assay), including chromogranin A (CHGA), doublecortin (DCX), dopadecarboxylase (DDC), paired-like homeobox 2b (PHOX2B), and tyrosine hydroxylase (TH) were detected in the BM and peripheral blood (PB) from patients using RT-PCR (8). Here, CHGA is linked to neuroblastoma.