Moreover, we can conclude that the expression of VE-cadherin, MMP-9, and MMP-2 is dependent on p38/MAPK and PI3K/Akt pathway simultaneously, while VEGFR-1 expression depends on p38/MAPK directly and have indirect relation with PI3K/Akt through IL-1β, which is also crucial in breast cancer cells progression. The gene discussed is CDH5; the disease is breast carcinoma.