Biochemical factors such as variation in CXC (an α chemokine subfamily), CXCL13, and granulocyte-macrophage colony-stimulating factor levels are assumed to play a pivotal role in the pathogenesis of SLE and MG; however, further studies are required to understand their exact mechanism and effect on the underlying autoimmune diseases.Following this, another precipitating factor for this overlap is believed to be thymectomy which is performed to eliminate MG symptoms. This evidence concerns the gene CXCL13 and systemic lupus erythematosus.