PPARA and Parkinson disease: In general, proteins related to amino acids metabolism, glucose and fatty acid (FA) mobilization and degradation to produce energy (glycolysis/gluconeogenesis, TCA cycle, pyruvate metabolism, FA degradation, PPAR signaling pathway, dicarboxylate metabolism, butanoate metabolism), protein folding, trafficking and degradation, metabolism of xenobiotics by cytochrome P450, GSH metabolism, antioxidant defense mechanisms, and non-alcoholic fatty acid liver or Parkinson’s diseases, among others, were highly affected in distress (S+P−) when compared to S−P− (Fig. 2A, Data S3).