However, researchers have found that Gly460Trp polymorphism in interaction with C1797T polymorphism of ADD2 increases the risk of hypertension in all women (adjusted relative risk, RR = 2.35, P=0.01) and postmenopausal subjects (RR = 2.92, P=0.03), but not in men. This evidence concerns the gene ADD2 and hypertensive disorder.