EPO and optic nerve disorder: Both final BCVA and thickness of retinal nerve fiber layer were reported to be significantly better in the EPO group.[23] In a prospective, non-comparative case series on 32 eyes of 16 patients,[24] one or two courses of intravenous EPO (20,000 units/day for three days) appeared to improve visual acuity in patients with methanol optic neuropathy.