Inflammatory cytokine IL-1β could promote the phosphorylation and nuclear translocation of NF-κB and activate the transcription of downstream tumor progression-related genes such as IL-1β, MMP9, and Bcl-2 to form another positive feedback loop, thus promoting the expression of antiapoptotic proteins and the proliferation and migration of tumor cells [37]. The gene discussed is MMP9; the disease is neoplasm.