AKT1 and myocardial infarction: It has been shown that adrenomedullin can protect against MI/RI-induced myocardial infarction, arrhythmias, and apoptosis by activating NO/cGMP to inhibit ROS-induced phosphorylation of Bax and p38 MAPK and activation of the Akt-Bad-Bcl-2 signaling pathway [263].