It was found that the biosynthesis of serum bone metabolism markers (s-CA, s-BAP, s-OC, and s-NTX) was significantly reduced in subjects with moderate (p=0.001) and severe (p=0.001) LBP compared to subjects with minimal LBP, as shown in Table 1 and Figure 1(d). The gene discussed is BGLAP; the disease is Low back pain.