The clinical importance of s-Ca, s-BAP, s-OC, and s-NTX bone markers was significantly reported to reflect cartilage and synovium tissue turnover, especially among patients with bone and musculoskeletal diseases such as rheumatoid arthritis (RA), osteoarthritis, and lower back pain [81–83]. The gene discussed is BGLAP; the disease is musculoskeletal system disorder.