FGF21 and type 2 diabetes mellitus: Another study by Huang et al. [6] revealed that adiponectin (ADPN) combined with fibroblast growth factor 21 (FGF-21) and adipocyte fatty acid binding protein (A-FABP) are of great clinical significance in the early diagnosis and risk prediction of T2DM and could serve as key markers for the prediction of T2DM onset in high-risk populations.