For example, CEP55 promoted the migration, invasion, and neurosphere formation of the glioma cell [28], promoted epithelial-mesenchymal transition in renal cell carcinoma through the PI3K/AKT/mTOR pathway [29], and promoted migration and invasion of esophageal squamous cell carcinoma via the PI3K/AKT pathway [30]. This evidence concerns the gene AKT1 and esophageal squamous cell carcinoma.