In addition, Yang et al. [22] demonstrated that cryptotanshinone can effectively reduce serum luteinizing hormone (LH) levels, the LH/follicle-stimulating hormone (FSH) ratio, and testosterone (T) levels, thereby reducing the expression of HMGB1, TLR4, and NFκB/p65 in ovarian tissue and granulosa cells and improving the symptoms of PCOS. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.