STAT3 and gastric cancer: The use of berberine, a compound isolated from medicinal plants such as Coptis chinensis, has been reported for preventing and treating GC via targeting the AMPK/HNF4α/WNT5A pathway [19], Akt/mTOR/p70S6/S6 pathway [20], interleukin-8 [21], and survivin and STAT3 [22].