As shown in Figures 11(a) -11(d), the level of serum ET-1 and TXB2 in the model group was significantly increased compared to the normal control group (P < 0.01), while the level of serum NO and PGI2 were reduced (P < 0.01, 0.05); it indicated that the model was successful for promoting the vasoconstrictor factor of the blood vessel in hypertension rats. The gene discussed is EDN1; the disease is hypertensive disorder.