Indeed, the patterns of host osteo-immunoinflammatory modulation in patients with peri-implantitis involve specific biomarkers (including IL-1, IL-8, IL-10, and MMP-8) and could be helpful in the early diagnostic of the disease or to cooperate to prognostic information related to the status of the peri-implant breakdown. The gene discussed is MMP8; the disease is Peri-Implantitis.