The microbiological and inflammatory pattern of peri-implantitis is the representation of a host immune response, which is characterized by the expression of proinflammatory mediators which are similar to those expressed by periodontitis, namely, IL-1β, IL-6, IL-17, and TNF-a, and mediators of osteolysis which are RANK, RANKL, Wnt5a and proteinase enzymes, MMP-2, MMP-9, and cathepsin K [19]. Here, TNF is linked to Peri-Implantitis.