MKI67 and neoplasm: In univariate analysis, we found an association of borderline significance among Ki-67 change subgroups and DFS (p=0,0596), with fewer recurrence for patients with high Ki-67 reduction (shown in Figure 2(b)), which was confirmed in multivariate analysis (95% CI 0,3589–0,93, hazard ratio = 0,5788, p=0,0256) after adjusting for covariates (age, tumor molecular subtype, clinical stage, and lymphovascular invasion) (shown in Table 3).