Lv et al. [23] found that apelin-13 can induce the migration and autophagy of human lung adenocarcinoma mediated by phosphorylated PAK1-filaggrin, indicating that apelin-13/APJ and its downstream signals are antitumor in patients with lung adenocarcinoma potential targets for metastasis therapy. This evidence concerns the gene APLNR and lung adenocarcinoma.